"The story is about the ascent of Handsome Jack, so it turns out, you'll find, that he starts his adventure perhaps with ethically great aims," Pitchfork said. "What's more, over the span of this diversion, you'll perceive how he turns into the horrendous, detestable scalawag he is in Borderlands 3 that appears to have appreciated removing individuals' eyeballs with a spoon. He wasn't generally so awful."
I think Handsome Jack died in Borderlands 2 - they say he may be mentioned in a side mission in Borderlands 3, but you are never going to see Handsome Jack come back as a character, although he was such a great villian!